1. The Liver section states normal <6 kPa, fibrosis 6–12.5 kPa, cirrhosis 12.5 kPa; the Mechanomarker section states normal <2.5 kPa, fibrosis 4.11 kPa, cirrhosis 4.71 kPa; later values of 9 and 13 kPa are also given. Which dataset/modality is correct, and how should Figure 9 be corrected?
2. You state that pathological stiffness hyperactivates Piezo1 and that targeting/inhibiting it may alleviate dysfunction, but then cite Piezo1 activation with Yoda1 as therapeutic. Please clarify whether Piezo1 should be inhibited or activated in asthma?
3. “Piezo1 in osteoblasts controls YAP-dependent expression of type II and IX collagens” is problematic: type II/IX are principally cartilage collagens, whereas osteoblasts produce type I collagen. Is this a misstatement (e.g., type I/IX), or is there direct evidence for type II/IX in osteoblasts?
4. “Heavy force (60 cm) … light force (10 cm)” uses length units for force; should these be cN (or g)?
5. Figure label errors. Figure 2 uses “Pgs2,” which appears to be a typo for Ptgs2/PGE2; Figure 9 uses undefined “URE,” whereas the text defines UE and MRE.
