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ScienceGuardians identifies anonymous intimidation & coordinated campaigns

Pharmacological roles of lncRNAs in diabetic retinopathy with a focus on oxidative stress and inflammation

Authors: Chengming Chen,Peng Ding,Weiming Yan,Zhaoyang Wang,Yanyan Lan,Xiaolong Yan,Tian Li,Jing Han
Journal: Biochemical Pharmacology
Publisher: Elsevier BV
Publish date: 2023-8
ISSN: 0006-2952 DOI: 10.1016/j.bcp.2023.115643
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The table states SNHG7 is “Down” regulated, but the text clearly states it is “significantly upregulated” (Page 7). This is a direct contradiction.
Incorrect Mechanism Descriptions: The table entry for H19 lists “miR-200b↓→VEGFA↑”, which is opposite to the authors’ own cited work (Thomas et al., 2019) where H19 prevents EndMT, suggesting it would decrease VEGFA. Similarly, the entry for MEG3 lists “VEGF↑” and “TGF-β1↑” as effects of downregulation, but the text says overexpressed MEG3 counters the increase in these factors. The arrows are used inconsistently and are often reversed, which is misleading for a reader trying to understand the pathways.

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