Taxonomy is internally inconsistent. The Abstract states that TME remodeling is structured around three principal mechanisms (electrochemical, paracrine, neuroimmune), but §4 and Fig. 3 propose eight modes, including PNI and neuro-microbic-oncology. Which is the paper’s operative classification? Please reconcile.
Nomenclature is inconsistent. The Abstract uses “neuro-micro-oncology”, §4.3.3 uses “neuro-microbic-oncology”, and Fig. 3H uses “Neuro-microbic-oncology.” Please define one term and clarify how it differs from neuro-immuno-oncology and the gut–brain axis.
Fig. 2 legend contradicts the text. The legend states reprogramming of existing nerves “from sympathetic nerves to parasympathetic nerves,” whereas §4.1 cites sensory-to-adrenergic neo-neurons in OCSCC. This is a direct evidence–legend mismatch.
“PNS” is used for two different systems. The text defines PNS as peripheral nervous system, but Fig. 5 legend defines PNS as parasympathetic nervous system. This makes Fig. 5 and §5.2 ambiguous and should be corrected.
Table 3 is cited repeatedly but absent. §7.1.1–7.1.3 cite Table 3 for antiepileptics, β-blockers, propranolol/anti-CTLA-4, etc., but no Table 3 is provided. Please supply it or remove the citations.
Section 6.3 heading is duplicated/misplaced. The first “6.3 Cognitive Dysfunction” appears before continuation of anorexia/cachexia text; the actual cognitive dysfunction section begins after a second “6.3” heading. Also, §7.3 refers to a prior cardio-oncology discussion that is not present in §6.
Citation errors affect specific claims. §4.1 cites [3–5] for colorectal NPC-derived sympathetic innervation, but these are cancer-hallmark/history references, not NPC data. §4.3.3 cites [125] for P. gingivalis TLR/NF-κB/JAK-STAT effects, but ref. 125 is a homoharringtonine lung-cancer study. §4.2 cites [14] for colorectal cancer denervation, but ref. 14 is basal cell carcinoma.
Fig. 6 legend/panel mismatch. The legend uses (1)–(3) while the panels are labeled A–C; the legend also begins “FIGURE 6 1,” and the panel descriptions do not match the panel labels. Please correct the figure numbering and legend.
