ScienceGuardians hosts publishers too
Secure Environment: Verified contributors only, ensuring meaningful and responsible discussions. Members can stay anonymous while verified, ensuring legitimacy and accountability.
Combatting Misconduct: A fortress against anonymous intimidation and coordinated campaigns, fostering evidence-based dialogue and protecting the academic community.
Resources and Training: Access classified content, participate in enlightening debates, and stay at the forefront of ethical practices.
Hack-Proof Platform: Your privacy is paramount. The identity information of users choosing to remain anonymous is securely stored offline.
Our Commitment:
Integrity and Accountability: Every account verified for credible and responsible engagement.
Inclusivity and Fairness: A platform where all voices in the scientific community are respected.
Support and Collaboration: Helping resolve issues delicately and constructively.
Participant
Given that the EPR effect in human melanoma is neither consistent nor sufficient for effective passive accumulation, on what scientific basis do you claim that liposomes, polymeric nanoparticles, and micelles can achieve “selective drug accumulation” and “reduced systemic toxicity” through passive targeting alone?
In Table 1, the entry for “Trametinib” describes “T-cell membranes derived from 19LF6 hybridomas carrying melanoma-specific anti-gp100/HLA-A2 T cell receptor (TCR).” However, 19LF6 is not a standard hybridoma designation—was this a typographical error? This raises concerns about the accuracy of the cited literature.
The review extensively discusses passive targeting via the EPR effect but fails to acknowledge the substantial body of literature questioning the clinical relevance of EPR in human tumors (e.g., the “EPR effect” has been criticized as primarily a murine phenomenon). Given that multiple clinical trials of EPR-dependent nanomedicines have failed to show improved outcomes, how do the authors justify continuing to present EPR as a cornerstone strategy without acknowledging these limitations?