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Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems

Authors: Sivakumar S. Moni,Jobran M. Moshi,Sabine Matou-Nasri,Shmoukh Alotaibi,Yousef M. Hawsawi,Mohamed Eltaib Elmobark,Ahlam Mohammed S. Hakami,Mohammed A. Jeraiby,Ahmed A. Sulayli,Hassan N. Moafa
Journal: Pharmaceutics
Publisher: MDPI AG
Publish date: 2025-2-24
ISSN: 1999-4923 DOI: 10.3390/pharmaceutics17030296
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Given that the EPR effect in human melanoma is neither consistent nor sufficient for effective passive accumulation, on what scientific basis do you claim that liposomes, polymeric nanoparticles, and micelles can achieve “selective drug accumulation” and “reduced systemic toxicity” through passive targeting alone?

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