The authors have discussed the pharmacology and toxicology of synthetic organoselenium compounds but the manuscript lacks clarity on the differential toxicity between acute and chronic exposure. While toxicity data for compounds like ebselen and diphenyl diselenide are presented, the mechanisms behind long-term toxicity are not fully explored. Moreover, while antioxidant properties are discussed, the authors do not address how these compounds interact with other cellular pathways, such as those involved in cancer or viral infections.
My last comment is that the role of selenium in immune function and cancer prevention is mentioned, but the U-shaped relationship between selenium levels and health outcomes is not adequately addressed. These gaps reduce the manuscript’s depth and practical applicability, and I would appreciate it if the authors could kindly share their insights on these points.