In Figure 2, the manuscript suggests that TGF-β treatment leads to OFD1 accumulation at centriolar satellites, which in turn suppresses ciliogenesis. However, previous studies indicate that the degradation of OFD1, rather than its accumulation, is necessary for promoting ciliary formation. Could you clarify how OFD1 accumulation at centriolar satellites specifically inhibits ciliogenesis in this context? Additionally, how do these findings reconcile with existing literature that supports the role of OFD1 degradation in cilia assembly?
