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S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD

Authors: Tao Guo,Zhe Dai,Ke You,Shyue-Fang Battaglia-Hsu,Juan Feng,Fengliang Wang,Bao Li,Jian Yang,Zhen Li
Publisher: Springer Science and Business Media LLC
Publish date: 2021-3-22
ISSN: 2041-4889 DOI: 10.1038/s41419-021-03591-1
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The authors state:

We found that SAM was depleted in NAFLD and that SAM supplementation ameliorated steatosis. In addition, in both high-fat diet-fed C57BL/6 rats and L02 cells treated with oleic acid (OA), ATRAP expression was downregulated at lower SAM concentrations.

Did the authors mean C57BL/6 mice? C57BL/6 rats do not exist.

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1 month, 1 week ago

We wish to inform the community that the previous comment regarding the mention of “C57BL/6 rats” was posted by an account that has since been permanently blocked from the ScienceGuardiansTM Post-Publication Peer Review Platform due to misuse of Northwestern University’s email system to create a deceptive alias for fraudulent purposes and identity misrepresentation, which constitutes a violation of our terms of conduct.

However, the scientific point raised remains valid. The term “C57BL/6 rats” is indeed incorrect, as C57BL/6 refers exclusively to an inbred mouse strain. This appears to be a genuine typographical or reporting error that warrants clarification.

We encourage the authors and readers to review this detail, and if appropriate, initiate the necessary corrections through the relevant journal channels.

ScienceGuardiansTM remains committed to scientific integrity, ensuring that while misconduct is addressed, valid concerns raised for the betterment of scientific literature are preserved.

Thank you for supporting the continued improvement of academic research.

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