The study acknowledges that HTP aerosols contain fewer harmful components than traditional cigarettes; however, some aspects require further attention. For example, the presence of unknown toxicants formed during repeated or uneven heating of HTP devices is mentioned but not investigated comprehensively. Could the authors elaborate on the methodologies needed to identify and quantify these unknown compounds? The discussion on reproductive system effects highlights contradictions between current findings and mainstream views, particularly regarding prenatal exposure. More in-depth analysis or contextualization of these contradictions would strengthen the conclusions.