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Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications

Authors: Philipp Pöschko,Caroline M. Berrou,Kaisa Pakari,Michael J. Ziegler,Christoph Kern,Birgit Koch,Joachim Wittbrodt,Richard Wombacher
Publisher: American Chemical Society (ACS)
Publish date: 2025-1-27
ISSN: 1554-8929,1554-8937 DOI: 10.1021/acschembio.4c00592
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Could the authors clarify why pOP induces protein proximity without irradiation in live medaka embryos (Figure 3C), while it remains inactive in mammalian cells without light exposure? Could this be due to enzymatic cleavage or other in vivo factors?

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