The paper overstates the clinical significance of berberine by treating preliminary or small-scale studies as conclusive, without establishing strong causal evidence. Additionally, potential toxicity risks are downplayed, and conflicting or negative findings are largely omitted, suggesting possible bias. A more balanced and thorough discussion of both benefits and risks would enhance the study’s scientific credibility. I recommend that the authors address these issues to improve methodological rigor and provide a clearer, more reliable assessment of berberine’s effects.
