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New onset abnormal eating behaviour following amygdalohippocampal laser ablation for mesial temporal epilepsy

Authors: Yosefa A. Modiano,Benjamin Eschler,Gabrielle Flores,Kathryn Synder
Publisher: Wiley
Publish date: 2025-2-26
ISSN: 1748-6645,1748-6653 DOI: 10.1111/jnp.12422
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While the findings provide valuable insights into the potential role of the mesial temporal structures in appetite and body image regulation, several key aspects require further clarification and discussion.

1. The authors attribute the observed eating behavior changes to altered limbic signaling post-surgery, particularly involving the amygdala and hippocampus. However, some important mechanistic considerations remain unexplored:

– The exact role of the amygdala vs. hippocampus in appetite regulation remains ambiguous. Given that only partial ablation was performed in the first procedure, could residual or compensatory activity in the remaining tissue contribute to the observed behavioral changes?
– The hypothalamic connection is critical in appetite regulation. While the study discusses amygdala-hypothalamus pathways, were there any indirect assessments of hypothalamic dysfunction, such as metabolic or endocrine evaluations (e.g., leptin/ghrelin levels)?
– Could the post-surgical neuroplasticity in other brain regions (e.g., insula, orbitofrontal cortex) have influenced the patient’s altered eating behavior rather than direct ablation effects?

2. The study provides neuropsychological data but lacks an in-depth discussion of its implications for the observed eating behavior:

– The patient demonstrated declines in semantic fluency and fine motor dexterity post-surgery. Could these changes indicate broader cognitive rigidity or obsessive tendencies that contributed to disordered eating patterns?
– The study does not report standardized psychiatric assessments (e.g., validated eating disorder scales, OCD measures). Would a more formal clinical evaluation provide a clearer differentiation between neurological and psychological factors?

3. Surgical and anatomical considerations:

– The second ablation targeted a remnant of the amygdala, yet the eating behavior changes persisted. Does this suggest that the first surgery was the primary driver of these changes, or could this indicate a broader network disruption?
– The study highlights dominant left-hemispheric involvement, but prior literature suggests stronger associations between right temporal damage and disordered eating. How do the authors reconcile this discrepancy?

This study raises fascinating questions about the limbic system’s role in appetite and eating behaviors. However, additional investigations, including larger patient cohorts, mechanistic neuroimaging, and standardized psychiatric evaluations, are necessary to fully understand whether such post-surgical changes are rare anomalies or part of a broader pattern in epilepsy surgery outcomes.

Would the authors consider further longitudinal follow-ups or additional case reports to assess the persistence and variability of such eating behavior changes post-surgery?

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