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HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease

Authors: Yin-Yuan Su,Hsuan-Cheng Huang,Yu-Ting Lin,Yi-Fang Chuang,Sheh-Yi Sheu,Chen-Ching Lin
Publisher: Springer Science and Business Media LLC
Publish date: 2025-2-1
ISSN: 1479-5876 DOI: 10.1186/s12967-024-05938-6
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The model demonstrates impressive predictive accuracy, how does it perform in identifying associations for rare or underrepresented diseases? Also, while the model integrates protein-drug affinity and disease similarity, how sensitive is it to variations in input data? Were any robustness tests conducted to evaluate performance across different drug-disease databases, or would model retraining be required for datasets with significantly different distributions?

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