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Extraction, Purification, Characterization, and Wound Healing Effects of Novel Prickly Pear (Opuntiaficus-indica (L.) Mill.) Heteropolysaccharides

Authors: Naourez Ktari,Wafa Gargouri,Lobna Jlaiel,Imen Trabelsi,Sirine Ben Slima,Sana Bardaa,Farida Bendali,Riadh Ben Salah
Publisher: MDPI AG
Publish date: 2024-10-21
ISSN: 1424-8247 DOI: 10.3390/ph17101410
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This study presents a compelling exploration of the wound-healing properties of polysaccharides extracted from prickly pear (PPPR). However, a few points warrant further clarification:

The study emphasizes the antioxidant and antibacterial properties of PPPR as critical contributors to wound healing. Could you elaborate on the specific mechanisms through which these properties facilitate tissue repair, particularly in diabetic models where oxidative stress and inflammation are key challenges?
The comparison between PPPR and Cytol Centella® cream indicates superior performance of PPPR, yet the biochemical basis for this distinction remains underexplored. Could you provide more details on the molecular interactions or pathways that might explain this efficacy?
While the extraction and characterization of PPPR are well-detailed, the scalability of this process for broader clinical application is not addressed. Are there potential challenges or limitations in large-scale production of this polysaccharide?

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