The study provides valuable insights into the neuroprotective effects of electroacupuncture in ACA/CPR, but a few areas could use further clarification. While the findings suggest that EA suppresses the P2X7R/NLRP3 pathway, were any off-target effects evaluated to rule out unintended interactions with other neuroinflammatory or neuroprotective mechanisms?
Additionally, given the clinical relevance of these findings, how do the authors see EA translating into human applications? Were any considerations made regarding differences in anatomical and physiological responses between rats and humans that might influence treatment efficacy?