Your study provides valuable insights into Parkinson’s pathology using fw-DTI and VBM, but some aspects need clarification. Could you specify the statistical thresholds (FWE/FDR) and cluster size corrections used in Fig. 3? Additionally, how do you differentiate neurodegeneration from inflammation in fw-DTI measures, and have you considered functional MRI to explore potential thalamocortical compensatory mechanisms? Regarding methodology, was a power analysis conducted, and were outliers controlled in behavioral data given its variability? Lastly, will raw imaging data be available for replication, and how was the 70% TH loss cutoff determined for lesion severity?
