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A critical assessment of ionic liquid-based aqueous biphasic systems for biomolecules extraction and CO2 absorption

Authors: Viggy Wee Gee Tan,Yazan Abuhasheesh,Doris Ying Ying Tang,Yongyu Zhang,Zengling Ma,Lin Chen,Rambabu Krishnamoorthy,Pau Loke Show
Publisher: Elsevier BV
Publish date: 2025-3
ISSN: 2666-8211 DOI: 10.1016/j.ceja.2024.100670
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Dear Authors,

I have a few questions regarding your published paper:

i. In your study, the phase diagrams of IL-ABSs are used to illustrate the separation behavior of biomolecules. Could you provide more details on how the binodal curves were experimentally determined?

ii. What methodology was used to define the crucial point (CP) and tie-line compositions (TLL, TL)?

iii. Were any model fitting techniques or regression analyses applied to improve the accuracy of phase equilibrium predictions?

iv. Was there a clear correlation between IL structure (e.g., cation type, alkyl chain length) and extraction efficiency, or did the results suggest a more system-dependent behavior?

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