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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

Authors: Niklas Finnberg,Andres J.P. Klein-Szanto,Wafik S. El-Deiry
Publisher: American Society for Clinical Investigation
Publish date: 2008-1-2
ISSN: 0021-9738 DOI: 10.1172/jci29900
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Concern about **Figure 2A**: * Boxes of the same color highlight overlapping areas in panels that are presented as different experiments.    

  • This topic was modified 1 day, 3 hours ago by elisabethbik.
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1 day, 3 hours ago

Dear Elisabeth: If you look at what you found, it is clear that when the first author assembled the figure, for the higher magnifications he mixed up the panels. The data is all there and it is pretty obvious. I have tried to reach Dr. Finnberg without success as he left academia years ago. However, I want to point out that if you read the paper you will see there is no difference in Ki67 among the 3 genotypes. No differences are claimed. That means it is a negative result. The finding has zero significance as far as the conclusions of the paper. Any scientific peer would see that. The work was conducted two decades ago and so it is unclear why you have chosen to target this paper. The important scientific findings were reproduced and extended in another important paper my lab published in JCI in March of 2025. The more recent work has relevance to radiation toxicities that patients face as well as radiation countermeasures. I have been unable to get my NIH grant funded by the nih perhaps because you and PubPeer have smeared my reputation. I have not heard from the JCI about this paper but i have responded to your finding.  W. El-Deiry

1 day, 2 hours ago

Thank you, Dr. El-Deiry, for replying here. Much appreciated!
Noone is trying to smear your reputation; we just noticed that several of your papers appear to have duplicated or mixed-up images, which might need to be corrected. The particular issue raised above appears to indeed be a mix-up, where images have not been matched carefully with the correct sample. Even if these are obvious errors, there amount of errors in this one figure raises doubt over the rigor applied to this experiment. I hope you can correct this and other errors. 

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