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Health Professionals’ Preferences for Next-Generation Sequencing in the Diagnosis of Suspected Genetic Disorders in the Paediatric Population

Authors: Mario Cesare Nurchis,Gerardo Altamura,Gian Marco Raspolini,Enrico Capobianco,Luca Salmasi,Gianfranco Damiani
Publisher: MDPI AG
Publish date: 2025-1-10
ISSN: 2075-4426 DOI: 10.3390/jpm15010025
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The study’s reliance on a small sample size (81 respondents) raises concerns about the generalizability of its findings, especially given the exclusion of 44 participants without a detailed discussion of their characteristics. Additionally, the exclusion of an opt-out option in the discrete choice experiment may lead to forced choices that do not align with real-world clinical decision-making, potentially inflating attribute importance. The significant discrepancies between WTP estimates in preference and WTP spaces suggest possible methodological weaknesses in the assumptions regarding cost sensitivity. I would thank the authors for sharing their thoughts on this issue.

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