It would be valuable to further explore the molecular mechanisms underlying these sex-specific responses, particularly the potential interplay between Grem1, estrogen, and other sex hormones.
Could the authors elaborate on how estrogen signaling might modulate Grem1 expression or activity in osteoclasts, and whether this interaction could explain the observed sex disparities in bone resorption and formation?
Are there plans to investigate the role of Grem1 in other bone-related conditions, such as osteoporosis, to assess its potential as a therapeutic target?