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Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Authors: Sean L. Zheng,Albert Henry,Douglas Cannie,Michael Lee,David Miller,Kathryn A. McGurk,Isabelle Bond,Xiao Xu,Hanane Issa,Catherine Francis,Antonio De Marvao,Pantazis I. Theotokis,Rachel J. Buchan,Doug Speed,Erik Abner,Lance Adams,Krishna G. Aragam,Johan Ärnlöv,Anna Axelsson Raja,Joshua D. Backman,John Baksi,Paul J. R. Barton,Kiran J. Biddinger,Eric Boersma,Jeffrey Brandimarto,Søren Brunak,Henning Bundgaard,David J. Carey,Philippe Charron,James P. Cook,Stuart A. Cook,Spiros Denaxas,Jean-François Deleuze,Alexander S. Doney,Perry Elliott,Christian Erikstrup,Tõnu Esko,Eric H. Farber-Eger,Chris Finan,Sophie Garnier,Jonas Ghouse,Vilmantas Giedraitis,Daniel F. Guðbjartsson,Christopher M. Haggerty,Brian P. Halliday,Anna Helgadottir,Harry Hemingway,Hans L. Hillege,Isabella Kardys,Lars Lind,Cecilia M. Lindgren,Brandon D. Lowery,Charlotte Manisty,Kenneth B. Margulies,James C. Moon,Ify R. Mordi,Michael P. Morley,Andrew D. Morris,Andrew P. Morris,Lori Morton,Mahdad Noursadeghi,Sisse R. Ostrowski,Anjali T. Owens,Colin N. A. Palmer,Antonis Pantazis,Ole B. V. Pedersen,Sanjay K. Prasad,Akshay Shekhar,Diane T. Smelser,Sundararajan Srinivasan,Kari Stefansson,Garðar Sveinbjörnsson,Petros Syrris,Mari-Liis Tammesoo,Upasana Tayal,Maris Teder-Laving,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Vinicius Tragante,David-Alexandre Trégouët,Thomas A. Treibel,Henrik Ullum,Ana M. Valdes,Jessica van Setten,Marion van Vugt,Abirami Veluchamy,W. M. Monique Verschuren,Eric Villard,Yifan Yang,Unknown Author,Mahdad Noursadeghi,Unknown Author,Ole B. V. Pedersen,Kari Stefansson,Unnur Thorsteinsdottir,Henrik Ullum,Unknown Author,Unknown Author,Folkert W. Asselbergs,Antonio De Marvao,Marie-Pierre Dube,Michael E. Dunn,Patrick T. Ellinor,Sophie Garnier,Chim C. Lang,Andrew P. Morris,Lori Morton,Colin N. A. Palmer,Nilesh J. Samani,Svati H. Shah,Akshay Shekhar,J. Gustav Smith,Sundarajan Srinivasan,Guðmundur Thorgeirsson,Ramachandran S. Vasan,Jessica van Setten,Marion van Vugt,Abirami Veluchamy,W. M. Monique Verschuuren,Eric Villard,Quinn Wells,Folkert W. Asselbergs,Thomas P. Cappola,Marie-Pierre Dube,Michael E. Dunn,Patrick T. Ellinor,Aroon D. Hingorani,Chim C. Lang,Nilesh J. Samani,Svati H. Shah,J. Gustav Smith,Ramachandran S. Vasan,Declan P. O’Regan,Hilma Holm,Michela Noseda,Quinn Wells,James S. Ware,R. Thomas Lumbers
Publisher: Springer Science and Business Media LLC
Publish date: 2024-11-21
ISSN: 1061-4036,1546-1718 DOI: 10.1038/s41588-024-01952-y
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GeneticMan
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While the study provides significant findings, the genetic and transcriptomic data focus predominantly on populations of European ancestry. This raises concerns about the generalizability of the results to other ethnic groups with differing genetic architectures. Could the authors elaborate on whether genetic heterogeneity in non-European populations might impact the identified loci and pathways? Additionally, given the complexity of gene-environment interactions, how might environmental factors, such as lifestyle or comorbidities, modulate the predictive accuracy of polygenic risk scores?

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