The study offers fascinating insights into the roles of FGF7 and FGF10 in promoting eccrine gland differentiation through the FGFR1/2-MEK1/2-ERK1/2 signaling pathway. However, I found it challenging to fully understand whether the interactions between FGFR1/2 and downstream signaling components like MEK1/2 and ERK1/2 were directly demonstrated. Were any specific interaction studies, such as co-immunoprecipitation or functional blocking experiments, performed to confirm these signaling events? Clarifying this aspect would significantly enhance the mechanistic understanding of this pathway’s role in organoid differentiation.
