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Repositioning and development of new treatments for neurodegenerative diseases: Focus on neuroinflammation

Authors: Bruno Dutra Arbo,Lucia Emanueli Schimith,Michele Goulart dos Santos,Mariana Appel Hort
Publisher: Elsevier BV
Publish date: 2022-3
ISSN: 0014-2999 DOI: 10.1016/j.ejphar.2022.174800
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The article provides a comprehensive analysis of drug repositioning strategies for neurodegenerative diseases, particularly focusing on neuroinflammation. Regarding the discussion on the potential timing of NSAID efficacy in Alzheimer’s disease, could you clarify how the evidence supports this pre-symptomatic window? Additionally, do the findings suggest any practical strategies for identifying at-risk populations who might benefit most from early intervention?

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